Assay Detail
Functional
CHEMBL4605031
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay
6
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms: Norbaeocystin, Baeocystin, Norpsilocin, and Aeruginascin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.34 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | 3.0 | 2 | 9.28 |
| CHEMBL65547 | PSILOCIN | 2.0 | 2 | 8.01 |
| CHEMBL4648350 | — | — | 2 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | EC50 | = | 0.5248 | nM | 9.28 |
| CHEMBL39 | SEROTONIN | EC50 | = | 0.53 | nM | 9.28 |
| CHEMBL65547 | PSILOCIN | EC50 | = | 9.772 | nM | 8.01 |
| CHEMBL65547 | PSILOCIN | EC50 | = | 9.9 | nM | 8.00 |
| CHEMBL4648350 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4648350 | — | EC50 | = | 19.05 | nM | 7.72 |