Assay Detail
Functional
CHEMBL4605047
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Antiproliferative activity against human NCI-H1975 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Suppression of Drug-Resistant Non-Small-Cell Lung Cancer with Inhibitors Targeting Minichromosomal Maintenance Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.64 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4633327 | — | — | 1 | 7.77 |
| CHEMBL4641475 | — | — | 1 | 7.62 |
| CHEMBL582107 | — | — | 1 | 7.11 |
| CHEMBL4635241 | — | — | 1 | 7.10 |
| CHEMBL4638640 | — | — | 1 | 6.60 |
| CHEMBL4639694 | — | — | 1 | 6.58 |
| CHEMBL4637221 | — | — | 1 | 6.55 |
| CHEMBL4646953 | — | — | 1 | 6.54 |
| CHEMBL4645622 | — | — | 1 | 6.08 |
| CHEMBL4641066 | — | — | 1 | 6.04 |
| CHEMBL4639251 | — | — | 1 | 5.06 |
| CHEMBL4636600 | — | — | 1 | - |
| CHEMBL4645075 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4633327 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4641475 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL582107 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4635241 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4638640 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4639694 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4637221 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4646953 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL4645622 | — | IC50 | = | 826.0 | nM | 6.08 |
| CHEMBL4641066 | — | IC50 | = | 918.0 | nM | 6.04 |
| CHEMBL4639251 | — | IC50 | = | 8727.0 | nM | 5.06 |
| CHEMBL4636600 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4645075 | — | IC50 | > | 10000.0 | nM | - |