Assay Detail
Binding
CHEMBL4605213
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LMP7 in human 20S immunoproteasome using Ac-ANW-AMC as substrate after 1 hr by fluorescence based microplate reader analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
LMP2 Inhibitors as a Potential Treatment for Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.42 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237875 | — | — | 1 | 7.42 |
| CHEMBL4100295 | — | — | 1 | - |
| CHEMBL4646371 | — | — | 1 | - |
| CHEMBL4649310 | — | — | 1 | - |
| CHEMBL4635132 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237875 | — | IC50 | = | 37.9 | nM | 7.42 |
| CHEMBL4100295 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4646371 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4649310 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4635132 | — | IC50 | > | 10000.0 | nM | - |