Assay Detail
ADMET
CHEMBL4605397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal His6-tagged rat DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL2383) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.57 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | 7.77 |
| CHEMBL1956285 | DSM-265 | 2.0 | 1 | 5.36 |
| CHEMBL4642145 | — | — | 1 | - |
| CHEMBL4649039 | — | — | 1 | - |
| CHEMBL4636879 | — | — | 1 | - |
| CHEMBL4633246 | — | — | 1 | - |
| CHEMBL4636553 | — | — | 1 | - |
| CHEMBL4635646 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1956285 | DSM-265 | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4642145 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4649039 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4636879 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4633246 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4636553 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4635646 | — | IC50 | - | — | - |