Assay Detail
Binding
CHEMBL4605536
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GLUT1 in human wild-type DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 2, facilitated glucose transporter member 1 (CHEMBL2535) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Optimization of Glucose Uptake Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.46 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4647311 | — | — | 1 | 7.44 |
| CHEMBL4645691 | — | — | 1 | 7.43 |
| CHEMBL4634839 | — | — | 1 | 7.32 |
| CHEMBL4448899 | BAY-876 | — | 1 | 7.30 |
| CHEMBL4645036 | — | — | 1 | 7.14 |
| CHEMBL4634011 | — | — | 1 | 6.99 |
| CHEMBL4649311 | — | — | 1 | 6.98 |
| CHEMBL4642046 | — | — | 1 | 6.89 |
| CHEMBL4645662 | — | — | 1 | 6.85 |
| CHEMBL4638542 | — | — | 1 | 6.84 |
| CHEMBL4634012 | — | — | 1 | 6.79 |
| CHEMBL4638234 | — | — | 1 | 6.75 |
| CHEMBL4633651 | — | — | 1 | 6.66 |
| CHEMBL4647401 | — | — | 1 | 6.62 |
| CHEMBL4632395 | — | — | 1 | 6.59 |
| CHEMBL4648466 | — | — | 1 | 6.54 |
| CHEMBL4648473 | — | — | 1 | 6.49 |
| CHEMBL4635864 | — | — | 1 | 6.47 |
| CHEMBL4638502 | — | — | 1 | 6.45 |
| CHEMBL4637134 | — | — | 1 | 6.36 |
| CHEMBL4632920 | — | — | 1 | 6.35 |
| CHEMBL4635564 | — | — | 1 | 6.34 |
| CHEMBL4641999 | — | — | 1 | 6.26 |
| CHEMBL4635844 | — | — | 1 | 6.25 |
| CHEMBL4633530 | — | — | 1 | 6.25 |
| CHEMBL4649021 | — | — | 1 | 6.18 |
| CHEMBL4637311 | — | — | 1 | 6.12 |
| CHEMBL4647586 | — | — | 1 | 6.10 |
| CHEMBL4649877 | — | — | 1 | 6.05 |
| CHEMBL4642809 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4647311 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4645691 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4634839 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4448899 | BAY-876 | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4645036 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4634011 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL4649311 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL4642046 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL4645662 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4638542 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL4634012 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL4638234 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL4633651 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4647401 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL4632395 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL4648466 | — | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL4648473 | — | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL4635864 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL4638502 | — | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL4637134 | — | IC50 | = | 441.0 | nM | 6.36 |
| CHEMBL4632920 | — | IC50 | = | 447.0 | nM | 6.35 |
| CHEMBL4635564 | — | IC50 | = | 459.0 | nM | 6.34 |
| CHEMBL4641999 | — | IC50 | = | 552.0 | nM | 6.26 |
| CHEMBL4635844 | — | IC50 | = | 565.0 | nM | 6.25 |
| CHEMBL4633530 | — | IC50 | = | 559.0 | nM | 6.25 |
| CHEMBL4649021 | — | IC50 | = | 666.0 | nM | 6.18 |
| CHEMBL4637311 | — | IC50 | = | 763.0 | nM | 6.12 |
| CHEMBL4647586 | — | IC50 | = | 789.0 | nM | 6.10 |
| CHEMBL4649877 | — | IC50 | = | 885.0 | nM | 6.05 |
| CHEMBL4642809 | — | IC50 | = | 914.0 | nM | 6.04 |
| CHEMBL4648189 | — | IC50 | = | 1048.0 | nM | 5.98 |
| CHEMBL4638556 | — | IC50 | = | 1112.0 | nM | 5.95 |
| CHEMBL4634395 | — | IC50 | = | 1266.0 | nM | 5.90 |
| CHEMBL4637262 | — | IC50 | = | 1458.0 | nM | 5.84 |
| CHEMBL4649871 | — | IC50 | = | 1578.0 | nM | 5.80 |
| CHEMBL4645739 | — | IC50 | = | 1828.0 | nM | 5.74 |
| CHEMBL4649211 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL4640792 | — | IC50 | = | 2711.0 | nM | 5.57 |
| CHEMBL4635322 | — | IC50 | > | 10000.0 | nM | - |