Assay Detail
Binding
CHEMBL4606154
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant HDAC7 pre-incubated for 15 mins before Ac-Leu-Gly-Lys(trifluroAc)-AMC substrate addition and measured after 60 mins by fluorescence based assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Achiral Derivatives of Hydroxamate AR-42 Potently Inhibit Class I HDAC Enzymes and Cancer Cell Proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.22 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4642874 | — | — | 1 | 6.68 |
| CHEMBL4634521 | — | — | 1 | 6.57 |
| CHEMBL4640356 | — | — | 1 | 6.33 |
| CHEMBL4639966 | — | — | 1 | 6.24 |
| CHEMBL191091 | — | — | 1 | 6.11 |
| CHEMBL4640415 | — | — | 1 | 6.04 |
| CHEMBL4636734 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4642874 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4634521 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4640356 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4639966 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL191091 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4640415 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4636734 | — | IC50 | = | 2500.0 | nM | 5.60 |