Assay Detail
ADMET
CHEMBL4606177
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Cytotoxicity against human NFF cells assessed as increase in intracellular caspase 3/7 release incubated for 72 hrs by Caspase-Glo 3/7 assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | NFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Achiral Derivatives of Hydroxamate AR-42 Potently Inhibit Class I HDAC Enzymes and Cancer Cell Proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 4.99 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4642874 | — | — | 1 | 5.37 |
| CHEMBL191091 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4642874 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL191091 | — | EC50 | = | 24300.0 | nM | 4.61 |