Assay Detail
Binding
CHEMBL4606556
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H3R expressed in baculovirus infected Sf9 insect cell membranes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
UR-DEBa242: A Py-5-Labeled Fluorescent Multipurpose Probe for Investigations on the Histamine H3 and H4 Receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.83 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4642520 | — | — | 1 | 9.04 |
| CHEMBL4635634 | — | — | 1 | 8.60 |
| CHEMBL4636487 | — | — | 1 | 7.93 |
| CHEMBL4634235 | — | — | 1 | 7.87 |
| CHEMBL4646286 | — | — | 1 | 6.34 |
| CHEMBL4633688 | — | — | 1 | 6.30 |
| CHEMBL4640263 | — | — | 1 | 6.07 |
| CHEMBL4634728 | — | — | 1 | 5.79 |
| CHEMBL4639472 | — | — | 1 | 5.62 |
| CHEMBL4634631 | — | — | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4642520 | — | Ki | = | 0.912 | nM | 9.04 |
| CHEMBL4635634 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL4636487 | — | Ki | = | 11.75 | nM | 7.93 |
| CHEMBL4634235 | — | Ki | = | 13.49 | nM | 7.87 |
| CHEMBL4646286 | — | Ki | = | 457.09 | nM | 6.34 |
| CHEMBL4633688 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL4640263 | — | Ki | = | 851.14 | nM | 6.07 |
| CHEMBL4634728 | — | Ki | = | 1621.81 | nM | 5.79 |
| CHEMBL4639472 | — | Ki | = | 2398.83 | nM | 5.62 |
| CHEMBL4634631 | — | Ki | = | 20417.38 | nM | 4.69 |