Assay Detail
Binding
CHEMBL4606616
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to 15N-labeled FKBP51 (1 to 140 residues) (unknown origin) expressed in Escherichia coli OD2N by two-dimensional 1H/15N HSQC NMR spectroscopy
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peptidyl-prolyl cis-trans isomerase FKBP5 (CHEMBL2052031) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Hybrid Screening Approach for Very Small Fragments: X-ray and Computational Screening on FKBP51.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 2.59 | 2.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL662 | — | — | 1 | 2.89 |
| CHEMBL12193 | — | — | 1 | 2.55 |
| CHEMBL1230309 | — | — | 1 | 2.54 |
| CHEMBL540 | IMIDAZOLE | — | 1 | 2.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL662 | — | Kd | = | 1300000.0 | nM | 2.89 |
| CHEMBL12193 | — | Kd | = | 2800000.0 | nM | 2.55 |
| CHEMBL1230309 | — | Kd | = | 2900000.0 | nM | 2.54 |
| CHEMBL540 | IMIDAZOLE | Kd | = | 4400000.0 | nM | 2.36 |