Assay Detail
Functional
CHEMBL4606642
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HBV infected in human HepG2.A64 cells containing reverse transcriptase L180M/T184L/M204V mutant assessed as reduction in viral replication incubated for 6 days by PCR analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of (1H-Pyrazolo[3,4-c]pyridin-5-yl)sulfonamide Analogues as Hepatitis B Virus Capsid Assembly Modulators by Conformation Constraint.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.97 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4647919 | — | — | 1 | 9.60 |
| CHEMBL4647397 | — | — | 1 | 8.66 |
| CHEMBL3742114 | — | — | 1 | 8.20 |
| CHEMBL4637119 | — | — | 1 | 7.32 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 6.08 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | - |
| CHEMBL5314362 | ENTECAVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4647919 | — | EC50 | = | 0.25 | nM | 9.60 |
| CHEMBL4647397 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3742114 | — | EC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4637119 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL141 | LAMIVUDINE | EC50 | > | 10000.0 | nM | - |
| CHEMBL5314362 | ENTECAVIR | EC50 | > | 10000.0 | nM | - |