Assay Detail
Functional
CHEMBL4606643
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Antiviral activity against multidrug-resistant HBV infected in human HepG2.1403F cells assessed as reduction in viral replication incubated for 6 days by PCR analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of (1H-Pyrazolo[3,4-c]pyridin-5-yl)sulfonamide Analogues as Hepatitis B Virus Capsid Assembly Modulators by Conformation Constraint.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.50 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4647919 | — | — | 1 | 9.48 |
| CHEMBL4647397 | — | — | 1 | 7.89 |
| CHEMBL3742114 | — | — | 1 | 7.38 |
| CHEMBL4637119 | — | — | 1 | 7.13 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 5.60 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | - |
| CHEMBL5314362 | ENTECAVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4647919 | — | EC50 | = | 0.33 | nM | 9.48 |
| CHEMBL4647397 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3742114 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4637119 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL141 | LAMIVUDINE | EC50 | > | 10000.0 | nM | - |
| CHEMBL5314362 | ENTECAVIR | EC50 | > | 10000.0 | nM | - |