Assay Detail
Binding
CHEMBL4610174
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Inhibition of human URAT1
4
Total Activities
4
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pharmacological urate-lowering approaches in chronic kidney disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.46 | 7.64 |
| EC50 | 1 | 4.92 | 4.92 |
| Ki | 1 | 7.24 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3707347 | VERINURAD | 2.0 | 1 | 7.64 |
| CHEMBL4640580 | EPAMINURAD | 1.0 | 1 | 7.24 |
| CHEMBL1765797 | MERBARONE | — | 1 | 5.27 |
| CHEMBL2103824 | ARHALOFENATE | 2.0 | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3707347 | VERINURAD | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4640580 | EPAMINURAD | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL1765797 | MERBARONE | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL2103824 | ARHALOFENATE | EC50 | = | 12000.0 | nM | 4.92 |