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Assay Detail

CHEMBL4610447

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antileishmanial activity against Leishmania orientalis MHOM/TH/2010/PCM2 axenic amastigotes incubated for 72 hrs by resazurin dye based colorimetric assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania orientalis
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania orientalis (CHEMBL4630671)
Type ORGANISM
Organism Leishmania orientalis

Publication

Synthesis and antileishmanial activity of fluorinated rhodacyanine analogues: The 'fluorine-walk' analysis.
Lasing T, Phumee A, Siriyasatien P, Chitchak K, Vanalabhpatana P, Mak KK, Hee Ng C, Vilaivan T, Khotavivattana T.
Bioorg Med Chem (2020) 28 : 115187 -115187
PubMed 31761725 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.88 7.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4643116 1 7.11
CHEMBL584818 1 7.10
CHEMBL4646044 1 7.10
CHEMBL4649254 1 7.09
CHEMBL4642489 1 7.07
CHEMBL267345 AMPHOTERICIN B 4.0 1 6.97
CHEMBL4649340 1 6.96
CHEMBL4636238 1 6.87
CHEMBL4638600 1 6.70
CHEMBL4634435 1 6.65
CHEMBL567070 1 6.04
CHEMBL4632522 1 -
CHEMBL4633984 1 -
CHEMBL4637803 1 -
CHEMBL4634611 1 -
CHEMBL4641930 1 -
CHEMBL4644768 1 -
CHEMBL4647513 1 -
CHEMBL125 MILTEFOSINE 4.0 1 -
CHEMBL4638482 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4643116 IC50 = 77.0 nM 7.11
CHEMBL584818 IC50 = 80.0 nM 7.10
CHEMBL4646044 IC50 = 80.0 nM 7.10
CHEMBL4649254 IC50 = 81.0 nM 7.09
CHEMBL4642489 IC50 = 85.0 nM 7.07
CHEMBL267345 AMPHOTERICIN B IC50 = 108.0 nM 6.97
CHEMBL4649340 IC50 = 110.0 nM 6.96
CHEMBL4636238 IC50 = 134.0 nM 6.87
CHEMBL4638600 IC50 = 200.0 nM 6.70
CHEMBL4634435 IC50 = 223.0 nM 6.65
CHEMBL567070 IC50 = 909.0 nM 6.04
CHEMBL4632522 IC50 - -
CHEMBL4633984 IC50 - -
CHEMBL4637803 IC50 - -
CHEMBL4634611 IC50 - -
CHEMBL4641930 IC50 - -
CHEMBL4644768 IC50 - -
CHEMBL4647513 IC50 - -
CHEMBL125 MILTEFOSINE IC50 - -
CHEMBL4638482 IC50 - -