Assay Detail
Binding
CHEMBL4610452
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
N-acylethanolamine-hydrolyzing acid amidase (CHEMBL4349) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of cyanamides as potent and selective N-acylethanolamine acid amidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 8.33 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4633233 | — | — | 1 | 9.46 |
| CHEMBL4640552 | — | — | 1 | 9.34 |
| CHEMBL4642793 | — | — | 1 | 9.33 |
| CHEMBL4635208 | — | — | 1 | 9.17 |
| CHEMBL4640519 | — | — | 1 | 9.07 |
| CHEMBL4644090 | — | — | 1 | 9.06 |
| CHEMBL4633213 | — | — | 1 | 9.05 |
| CHEMBL4649536 | — | — | 1 | 9.03 |
| CHEMBL4637701 | — | — | 1 | 8.99 |
| CHEMBL4646880 | — | — | 1 | 8.96 |
| CHEMBL4632623 | — | — | 1 | 8.85 |
| CHEMBL4645560 | — | — | 1 | 8.80 |
| CHEMBL4635238 | — | — | 1 | 8.80 |
| CHEMBL4646586 | — | — | 1 | 8.80 |
| CHEMBL4641417 | — | — | 1 | 8.74 |
| CHEMBL4643427 | — | — | 1 | 8.60 |
| CHEMBL4642907 | — | — | 1 | 8.55 |
| CHEMBL4636322 | — | — | 1 | 8.55 |
| CHEMBL4637755 | — | — | 1 | 8.55 |
| CHEMBL4643588 | — | — | 1 | 8.49 |
| CHEMBL4645262 | — | — | 1 | 8.47 |
| CHEMBL4638402 | — | — | 1 | 8.34 |
| CHEMBL4638779 | — | — | 1 | 8.24 |
| CHEMBL4639554 | — | — | 1 | 8.24 |
| CHEMBL4643074 | — | — | 1 | 8.21 |
| CHEMBL4649749 | — | — | 1 | 8.19 |
| CHEMBL4634952 | — | — | 1 | 8.18 |
| CHEMBL4637132 | — | — | 1 | 8.07 |
| CHEMBL4637050 | — | — | 1 | 8.04 |
| CHEMBL4641400 | — | — | 1 | 8.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4633233 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL4640552 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL4642793 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL4635208 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL4640519 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL4644090 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL4633213 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL4649536 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL4637701 | — | IC50 | = | 1.03 | nM | 8.99 |
| CHEMBL4646880 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4632623 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4645560 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4646586 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4635238 | — | IC50 | = | 1.58 | nM | 8.80 |
| CHEMBL4641417 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4643427 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4642907 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4636322 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4637755 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4643588 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4645262 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4638402 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4638779 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4639554 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4643074 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL4649749 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4634952 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL4637132 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL4637050 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL4641400 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL4632779 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL4636756 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4648948 | — | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL4637179 | — | IC50 | = | 23.7 | nM | 7.62 |
| CHEMBL4645479 | — | IC50 | = | 26.4 | nM | 7.58 |
| CHEMBL4633126 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4641015 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4636537 | — | IC50 | = | 67.5 | nM | 7.17 |
| CHEMBL4643165 | — | IC50 | = | 74.7 | nM | 7.13 |
| CHEMBL4644779 | — | IC50 | = | 91.2 | nM | 7.04 |
| CHEMBL4643680 | — | IC50 | = | 315.0 | nM | 6.50 |