Assay Detail
Functional
CHEMBL4610484
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Antiproliferative activity against human MOLM13 cells assessed as reduction in cell viability measured after 48 hrs by CellTiter-Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.56 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4633483 | — | — | 1 | 7.28 |
| CHEMBL4643122 | — | — | 1 | 6.75 |
| CHEMBL4643002 | — | — | 1 | 6.75 |
| CHEMBL4579153 | — | — | 1 | 5.47 |
| CHEMBL4637174 | — | — | 1 | - |
| CHEMBL4642038 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4633483 | — | IC50 | = | 51.96 | nM | 7.28 |
| CHEMBL4643122 | — | IC50 | = | 176.7 | nM | 6.75 |
| CHEMBL4643002 | — | IC50 | = | 179.5 | nM | 6.75 |
| CHEMBL4579153 | — | IC50 | = | 3369.0 | nM | 5.47 |
| CHEMBL4637174 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4642038 | — | IC50 | > | 10000.0 | nM | - |