Assay Detail
Binding
CHEMBL4610657
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Inhibition of recombinant human HDAC4
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresistant cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 4.71 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4456445 | — | — | 1 | 6.77 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 4.55 |
| CHEMBL4639388 | — | — | 1 | 4.50 |
| CHEMBL4645688 | — | — | 1 | 4.31 |
| CHEMBL4638018 | — | — | 1 | 4.08 |
| CHEMBL4643795 | — | — | 1 | 4.03 |
| CHEMBL4645307 | — | — | 1 | - |
| CHEMBL4638555 | — | — | 1 | - |
| CHEMBL4636427 | — | — | 1 | - |
| CHEMBL4635256 | — | — | 1 | - |
| CHEMBL4643138 | — | — | 1 | - |
| CHEMBL2312168 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4456445 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL98 | VORINOSTAT | Ki | = | 28400.0 | nM | 4.55 |
| CHEMBL4639388 | — | Ki | = | 31800.0 | nM | 4.50 |
| CHEMBL4645688 | — | Ki | = | 49200.0 | nM | 4.31 |
| CHEMBL4638018 | — | Ki | = | 83700.0 | nM | 4.08 |
| CHEMBL4643795 | — | Ki | = | 93100.0 | nM | 4.03 |
| CHEMBL4645307 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4638555 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4636427 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4635256 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4643138 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL2312168 | — | Ki | > | 100000.0 | nM | - |