Assay Detail
Functional
CHEMBL4610795
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Antiproliferative activity against human Raji cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Raji |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of boron-containing diphenylpyrimidines as potent BTK and JAK3 dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.23 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4642642 | — | — | 1 | 5.77 |
| CHEMBL4648837 | — | — | 1 | 5.17 |
| CHEMBL3301625 | SPEBRUTINIB | 2.0 | 1 | 4.75 |
| CHEMBL1873475 | IBRUTINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4642642 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4648837 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL3301625 | SPEBRUTINIB | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL1873475 | IBRUTINIB | IC50 | > | 20000.0 | nM | - |