Assay Detail
Functional
CHEMBL4611016
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Cytotoxicity against human HCT116 cells assessed as inhibition of cell growth
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel hybrid molecules of 3,5-bis(benzylidene)-4-piperidones and dichloroacetic acid which demonstrate potent tumour-selective cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.54 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4644654 | — | — | 1 | 7.52 |
| CHEMBL4636732 | — | — | 1 | 7.52 |
| CHEMBL4644904 | — | — | 1 | 7.40 |
| CHEMBL4644164 | — | — | 1 | 7.40 |
| CHEMBL4638546 | — | — | 1 | 7.30 |
| CHEMBL4637241 | — | — | 1 | 7.22 |
| CHEMBL4639410 | — | — | 1 | 6.96 |
| CHEMBL4643806 | — | — | 1 | 6.96 |
| CHEMBL4637045 | — | — | 1 | 6.89 |
| CHEMBL4645527 | — | — | 1 | 6.68 |
| CHEMBL4635647 | — | — | 1 | 6.64 |
| CHEMBL4644692 | — | — | 1 | 6.64 |
| CHEMBL4637754 | — | — | 1 | 6.57 |
| CHEMBL1993449 | — | — | 1 | 6.55 |
| CHEMBL4643361 | — | — | 1 | 6.50 |
| CHEMBL154716 | — | — | 1 | 5.46 |
| CHEMBL4633726 | — | — | 1 | 5.42 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.40 |
| CHEMBL4643807 | — | — | 1 | 4.88 |
| CHEMBL306823 | SODIUM DICHLOROACETATE | 3.0 | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4644654 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4636732 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4644904 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4644164 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4638546 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4637241 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4639410 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4643806 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4637045 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4645527 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4635647 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4644692 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4637754 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1993449 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4643361 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL154716 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4633726 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL4643807 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL306823 | SODIUM DICHLOROACETATE | IC50 | = | 14800.0 | nM | 4.83 |