Assay Detail
Binding
CHEMBL4611425
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Keap1 (unknown origin) by SPR assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Kelch-like ECH-associated protein 1 (CHEMBL2069156) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 8.20 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4644995 | — | — | 1 | 10.15 |
| CHEMBL4643134 | — | — | 1 | 9.15 |
| CHEMBL4633657 | — | — | 1 | 9.06 |
| CHEMBL4634531 | — | — | 1 | 8.72 |
| CHEMBL4642419 | — | — | 1 | 8.57 |
| CHEMBL4635041 | — | — | 1 | 7.87 |
| CHEMBL4640695 | — | — | 1 | 7.69 |
| CHEMBL4635896 | — | — | 1 | 7.25 |
| CHEMBL4637979 | — | — | 1 | 7.22 |
| CHEMBL2402207 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4644995 | — | Kd | = | 0.07 | nM | 10.15 |
| CHEMBL4643134 | — | Kd | = | 0.7 | nM | 9.15 |
| CHEMBL4633657 | — | Kd | = | 0.88 | nM | 9.06 |
| CHEMBL4634531 | — | Kd | = | 1.91 | nM | 8.72 |
| CHEMBL4642419 | — | Kd | = | 2.7 | nM | 8.57 |
| CHEMBL4635041 | — | Kd | = | 13.5 | nM | 7.87 |
| CHEMBL4640695 | — | Kd | = | 20.5 | nM | 7.69 |
| CHEMBL4635896 | — | Kd | = | 56.0 | nM | 7.25 |
| CHEMBL4637979 | — | Kd | = | 59.5 | nM | 7.22 |
| CHEMBL2402207 | — | Kd | = | 500.0 | nM | 6.30 |