Assay Detail
Binding
CHEMBL4611642
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Inhibition of recombinant human activated coagulation factor XI using pyro-Glu-Pro-Arg-pNA as substrate by spectrophotometry
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 8.39 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4071545 | — | — | 1 | 9.80 |
| CHEMBL3699175 | — | — | 1 | 9.66 |
| CHEMBL4632633 | — | — | 1 | 9.51 |
| CHEMBL4640111 | — | — | 1 | 9.34 |
| CHEMBL3699176 | — | — | 1 | 9.21 |
| CHEMBL4641689 | — | — | 1 | 9.17 |
| CHEMBL3676167 | — | — | 1 | 9.00 |
| CHEMBL4647704 | — | — | 1 | 8.96 |
| CHEMBL4634088 | — | — | 1 | 8.89 |
| CHEMBL4637778 | — | — | 1 | 8.70 |
| CHEMBL4645389 | — | — | 1 | 8.60 |
| CHEMBL4643121 | — | — | 1 | 8.59 |
| CHEMBL4633349 | — | — | 1 | 8.47 |
| CHEMBL4635313 | — | — | 1 | 8.44 |
| CHEMBL4634869 | — | — | 1 | 8.29 |
| CHEMBL4635248 | — | — | 1 | 8.22 |
| CHEMBL4642584 | — | — | 1 | 8.08 |
| CHEMBL4640474 | — | — | 1 | 7.92 |
| CHEMBL3699163 | — | — | 1 | 7.80 |
| CHEMBL4647369 | — | — | 1 | 7.80 |
| CHEMBL4637252 | — | — | 1 | 7.62 |
| CHEMBL4646216 | — | — | 1 | 7.32 |
| CHEMBL4647199 | — | — | 1 | 7.28 |
| CHEMBL3699189 | — | — | 1 | 6.61 |
| CHEMBL4634680 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4071545 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL3699175 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL4632633 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL4640111 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL3699176 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL4641689 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL3676167 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4647704 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL4634088 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL4637778 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4645389 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL4643121 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL4633349 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL4635313 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL4634869 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL4635248 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4642584 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL4640474 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3699163 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4647369 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4637252 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL4646216 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL4647199 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL3699189 | — | Ki | = | 245.0 | nM | 6.61 |
| CHEMBL4634680 | — | Ki | = | 370.0 | nM | 6.43 |