Assay Detail
Binding
CHEMBL4612141
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PTP1B (1 to 321 residues) expressed in Escherichia coli using p-nitrophenyl phosphate as substrate incubated for 30 mins
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Prenylated Phenolic Compounds from the Aerial Parts of <i>Glycyrrhiza uralensis</i> as PTP1B and α-Glucosidase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.28 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256340 | LESPEDEZAFLAVANONE B | — | 1 | 5.68 |
| CHEMBL494252 | — | — | 1 | 5.64 |
| CHEMBL3808735 | — | — | 1 | 5.48 |
| CHEMBL4638191 | — | — | 1 | 5.37 |
| CHEMBL4647021 | — | — | 1 | 5.36 |
| CHEMBL3810179 | — | — | 1 | 5.35 |
| CHEMBL4638927 | — | — | 1 | 5.32 |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 5.29 |
| CHEMBL3809337 | — | — | 1 | 5.28 |
| CHEMBL4639007 | — | — | 1 | 5.28 |
| CHEMBL1929043 | LICORICIDIN | — | 1 | 5.23 |
| CHEMBL4639637 | — | — | 1 | 5.23 |
| CHEMBL4636630 | — | — | 1 | 5.17 |
| CHEMBL3810262 | — | — | 1 | 5.16 |
| CHEMBL4634824 | — | — | 1 | 5.14 |
| CHEMBL3808919 | — | — | 1 | 5.12 |
| CHEMBL3809403 | — | — | 1 | 5.11 |
| CHEMBL4638414 | — | — | 1 | 5.08 |
| CHEMBL232935 | 2'-O-DEMETHYLBIDWILLOL B | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256340 | LESPEDEZAFLAVANONE B | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL494252 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3808735 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4638191 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4647021 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3810179 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4638927 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL169 | URSOLIC ACID | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL3809337 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4639007 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL1929043 | LICORICIDIN | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4639637 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4636630 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3810262 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4634824 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL3808919 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL3809403 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4638414 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL232935 | 2'-O-DEMETHYLBIDWILLOL B | IC50 | = | 9200.0 | nM | 5.04 |