Assay Detail
Binding
CHEMBL4612466
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SERCA1 in rat INS-1E cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (CHEMBL3585236) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Phenolic Compounds from <i>Morus nigra</i> Regulate Viability and Apoptosis of Pancreatic β-Cells Possibly via SERCA Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.55 | 4.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4648427 | — | — | 1 | 4.74 |
| CHEMBL4637788 | — | — | 1 | 4.74 |
| CHEMBL4173326 | — | — | 1 | 4.54 |
| CHEMBL464006 | MORUSIN | — | 1 | 4.54 |
| CHEMBL1096940 | — | — | 1 | 4.19 |
| CHEMBL380456 | (+/-)-MORACIN P | — | 1 | - |
| CHEMBL205924 | MORACIN O | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4648427 | — | IC50 | = | 18220.0 | nM | 4.74 |
| CHEMBL4637788 | — | IC50 | = | 18170.0 | nM | 4.74 |
| CHEMBL4173326 | — | IC50 | = | 28650.0 | nM | 4.54 |
| CHEMBL464006 | MORUSIN | IC50 | = | 28650.0 | nM | 4.54 |
| CHEMBL1096940 | — | IC50 | = | 64820.0 | nM | 4.19 |
| CHEMBL380456 | (+/-)-MORACIN P | IC50 | = | 108600.0 | nM | - |
| CHEMBL205924 | MORACIN O | IC50 | = | 111400.0 | nM | - |