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Assay Detail

CHEMBL4612832

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV2 ROD infected in human CEM/0 cells assessed as inhibition of viral-induced giant cell formation incubated for 4 to 5 days by microscopy
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Lipophilic Triphosphate Prodrugs of Various Nucleoside Analogues.
Jia X, Schols D, Meier C.
J Med Chem (2020) 63 : 6991 -7007
PubMed 32515595 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 26 6.62 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4640694 1 10.00
CHEMBL129 ZIDOVUDINE 4.0 1 8.35
CHEMBL4635962 1 8.32
CHEMBL4641032 1 8.06
CHEMBL4641725 1 7.92
CHEMBL4646773 1 7.85
CHEMBL885 EMTRICITABINE 4.0 1 7.80
CHEMBL4639306 1 6.77
CHEMBL991 STAVUDINE 4.0 1 6.51
CHEMBL4639002 1 6.50
CHEMBL4635703 1 6.44
CHEMBL4645259 1 6.00
CHEMBL4634747 1 5.88
CHEMBL4643804 1 5.62
CHEMBL52609 DOXRIBTIMINE 2.0 1 5.46
CHEMBL4642500 1 5.44
CHEMBL4637670 1 5.11
CHEMBL4641662 1 4.95
CHEMBL27473 1 4.92
CHEMBL1460 DIDANOSINE 4.0 1 4.52
CHEMBL4642943 1 -
CHEMBL2106991 RALURIDINE 1.0 1 -
CHEMBL48012 1 -
CHEMBL4648353 1 -
CHEMBL31634 BRIVUDINE 2.0 1 -
CHEMBL4640737 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4640694 EC50 = 0.1 nM 10.00
CHEMBL129 ZIDOVUDINE EC50 = 4.5 nM 8.35
CHEMBL4635962 EC50 = 4.8 nM 8.32
CHEMBL4641032 EC50 = 8.7 nM 8.06
CHEMBL4641725 EC50 = 12.0 nM 7.92
CHEMBL4646773 EC50 = 14.0 nM 7.85
CHEMBL885 EMTRICITABINE EC50 = 16.0 nM 7.80
CHEMBL4639306 EC50 = 170.0 nM 6.77
CHEMBL991 STAVUDINE EC50 = 310.0 nM 6.51
CHEMBL4639002 EC50 = 320.0 nM 6.50
CHEMBL4635703 EC50 = 360.0 nM 6.44
CHEMBL4645259 EC50 = 1000.0 nM 6.00
CHEMBL4634747 EC50 = 1320.0 nM 5.88
CHEMBL4643804 EC50 = 2370.0 nM 5.62
CHEMBL52609 DOXRIBTIMINE EC50 = 3470.0 nM 5.46
CHEMBL4642500 EC50 = 3600.0 nM 5.44
CHEMBL4637670 EC50 = 7780.0 nM 5.11
CHEMBL4641662 EC50 = 11250.0 nM 4.95
CHEMBL27473 EC50 = 12000.0 nM 4.92
CHEMBL1460 DIDANOSINE EC50 = 30000.0 nM 4.52
CHEMBL4642943 EC50 > 100000.0 nM -
CHEMBL2106991 RALURIDINE EC50 > 250000.0 nM -
CHEMBL48012 EC50 > 250000.0 nM -
CHEMBL4648353 EC50 > 44000.0 nM -
CHEMBL31634 BRIVUDINE EC50 > 250000.0 nM -
CHEMBL4640737 EC50 > 45000.0 nM -