Assay Detail
Binding
CHEMBL4612966
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Inhibition of BRD4 bromodomain 1 (unknown origin) by AlphaScreen displacement assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Structure-Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6<i>H</i>-benzo[<i>e</i>]pyrimido[5,4-<i>b</i>][1,4]diazepin-6-one Scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.85 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4636475 | — | — | 1 | 6.90 |
| CHEMBL4643632 | — | — | 1 | 6.28 |
| CHEMBL4634326 | — | — | 1 | 6.08 |
| CHEMBL1673039 | — | — | 1 | 6.05 |
| CHEMBL4649318 | — | — | 1 | 5.92 |
| CHEMBL4640016 | — | — | 1 | 5.80 |
| CHEMBL4646882 | — | — | 1 | 5.62 |
| CHEMBL1673048 | — | — | 1 | 5.38 |
| CHEMBL4644273 | — | — | 1 | 5.34 |
| CHEMBL4635720 | — | — | 1 | 5.13 |
| CHEMBL1672987 | — | — | 1 | - |
| CHEMBL4639395 | — | — | 1 | - |
| CHEMBL4641263 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4636475 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL4643632 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4634326 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL1673039 | — | IC50 | = | 888.0 | nM | 6.05 |
| CHEMBL4649318 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4640016 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL4646882 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL1673048 | — | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL4644273 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4635720 | — | IC50 | = | 7490.0 | nM | 5.13 |
| CHEMBL1672987 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4639395 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4641263 | — | IC50 | > | 10000.0 | nM | - |