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Assay Detail

CHEMBL4613060

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of human KARPAS422 cells incubated for 7 days by WST8 assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KARPAS-422
Confidence 1 — Organism
Curated By Autocuration

Target

KARPAS-422 (CHEMBL2366368)
Type CELL-LINE
Organism Homo sapiens

Publication

EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development.
Rej RK, Wang C, Lu J, Wang M, Petrunak E, Zawacki KP, McEachern D, Fernandez-Salas E, Yang CY, Wang L, Li R, Chinnaswamy K, Wen B, Sun D, Stuckey J, Zhou Y, Chen J, Tang G, Wang S.
J Med Chem (2020) 63 : 7252 -7267
PubMed 32580550 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 35 7.43 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4637520 1 9.30
CHEMBL4645310 1 8.85
CHEMBL4645324 1 8.85
CHEMBL4649099 1 8.80
CHEMBL4644746 1 8.77
CHEMBL4638412 1 8.77
CHEMBL4640949 1 8.66
CHEMBL4637096 1 8.62
CHEMBL4635558 1 8.55
CHEMBL4640556 1 8.54
CHEMBL4642335 1 8.51
CHEMBL4633469 1 8.44
CHEMBL4643880 1 8.28
CHEMBL4639197 1 8.19
CHEMBL4648753 1 8.09
CHEMBL4634654 1 8.09
CHEMBL4645381 1 7.92
CHEMBL4649861 1 7.82
CHEMBL4642454 1 7.54
CHEMBL4647900 1 7.28
CHEMBL4637475 1 7.22
CHEMBL4638385 1 6.92
CHEMBL4634939 1 6.90
CHEMBL4065484 1 6.75
CHEMBL4637975 1 6.68
CHEMBL4644450 1 6.52
CHEMBL4637141 1 6.52
CHEMBL4645585 1 6.00
CHEMBL4649754 1 5.72
CHEMBL4647928 1 5.62

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4637520 IC50 = 0.5 nM 9.30
CHEMBL4645310 IC50 = 1.4 nM 8.85
CHEMBL4645324 IC50 = 1.4 nM 8.85
CHEMBL4649099 IC50 = 1.6 nM 8.80
CHEMBL4644746 IC50 = 1.7 nM 8.77
CHEMBL4638412 IC50 = 1.7 nM 8.77
CHEMBL4640949 IC50 = 2.2 nM 8.66
CHEMBL4637096 IC50 = 2.4 nM 8.62
CHEMBL4635558 IC50 = 2.8 nM 8.55
CHEMBL4640556 IC50 = 2.9 nM 8.54
CHEMBL4642335 IC50 = 3.1 nM 8.51
CHEMBL4633469 IC50 = 3.6 nM 8.44
CHEMBL4643880 IC50 = 5.2 nM 8.28
CHEMBL4639197 IC50 = 6.5 nM 8.19
CHEMBL4634654 IC50 = 8.2 nM 8.09
CHEMBL4648753 IC50 = 8.1 nM 8.09
CHEMBL4645381 IC50 = 12.0 nM 7.92
CHEMBL4649861 IC50 = 15.3 nM 7.82
CHEMBL4642454 IC50 = 29.0 nM 7.54
CHEMBL4647900 IC50 = 52.0 nM 7.28
CHEMBL4637475 IC50 = 60.0 nM 7.22
CHEMBL4638385 IC50 = 120.0 nM 6.92
CHEMBL4634939 IC50 = 126.0 nM 6.90
CHEMBL4065484 IC50 = 180.0 nM 6.75
CHEMBL4637975 IC50 = 210.0 nM 6.68
CHEMBL4637141 IC50 = 300.0 nM 6.52
CHEMBL4644450 IC50 = 300.0 nM 6.52
CHEMBL4645585 IC50 = 1000.0 nM 6.00
CHEMBL4649754 IC50 = 1900.0 nM 5.72
CHEMBL4647928 IC50 = 2400.0 nM 5.62
CHEMBL4070157 IC50 = 2600.0 nM 5.58
CHEMBL4636851 IC50 = 2700.0 nM 5.57
CHEMBL4634893 IC50 = 3000.0 nM 5.52
CHEMBL4645511 IC50 = 4300.0 nM 5.37
CHEMBL4638382 IC50 = 6300.0 nM 5.20