Compound Detail
CHEMBL4642335
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Basic Information
| ChEMBL ID | CHEMBL4642335 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IEJBULVHHQXFQG-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
442.5
MW (Da)
2.22
ALogP
9
HBA
1
HBD
103.4
PSA (Ų)
0.51
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Pfeiffer CHEMBL4296489 | IC50 | 9.57 | 9.57 | 0.3 | 1 |
| Polycomb protein EED CHEMBL2189117 | IC50 | 9.3 | 9.3 | 0.5 | 1 |
| KARPAS-422 CHEMBL2366368 | IC50 | 8.51 | 8.51 | 3.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Pfeiffer | IC50 | = | 0.27 | nM | 9.57 | Growth inhibition of human Pfeiffer cells incubated for 7 days by WST8 assay | 32580550 |
| Polycomb protein EED | IC50 | = | 0.5 | nM | 9.3 | Inhibition of EED ( 1 to 441 residues) (unknown origin) pre-incubated for 15 min... | 32580550 |
| KARPAS-422 | IC50 | = | 3.1 | nM | 8.51 | Growth inhibition of human KARPAS422 cells incubated for 7 days by WST8 assay | 32580550 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32580550 | 10.1021/acs.jmedchem.0c00479 | ADMET | 3 |
| 32580550 | 10.1021/acs.jmedchem.0c00479 | Polycomb protein EED | 1 |
| 32580550 | 10.1021/acs.jmedchem.0c00479 | KARPAS-422 | 1 |
| 32580550 | 10.1021/acs.jmedchem.0c00479 | Pfeiffer | 1 |
Data from ChEMBL 36 via Core Engine