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Assay Detail

CHEMBL4613061

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of human Pfeiffer cells incubated for 7 days by WST8 assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Pfeiffer
Confidence 1 — Organism
Curated By Autocuration

Target

Pfeiffer (CHEMBL4296489)
Type CELL-LINE
Organism Homo sapiens

Publication

EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development.
Rej RK, Wang C, Lu J, Wang M, Petrunak E, Zawacki KP, McEachern D, Fernandez-Salas E, Yang CY, Wang L, Li R, Chinnaswamy K, Wen B, Sun D, Stuckey J, Zhou Y, Chen J, Tang G, Wang S.
J Med Chem (2020) 63 : 7252 -7267
PubMed 32580550 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 10.27 10.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4649099 1 10.70
CHEMBL4637520 1 10.70
CHEMBL4637096 1 10.70
CHEMBL4645324 1 10.70
CHEMBL4645310 1 10.52
CHEMBL4638412 1 10.52
CHEMBL4644746 1 10.30
CHEMBL4635558 1 10.15
CHEMBL4633469 1 10.10
CHEMBL4643880 1 9.92
CHEMBL4642335 1 9.57
CHEMBL4640556 1 9.30
CHEMBL4640949 1 -
CHEMBL4647900 1 -
CHEMBL4642454 1 -
CHEMBL4649861 1 -
CHEMBL4634939 1 -
CHEMBL4639197 1 -
CHEMBL4634654 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4649099 IC50 = 0.02 nM 10.70
CHEMBL4637520 IC50 = 0.02 nM 10.70
CHEMBL4637096 IC50 = 0.02 nM 10.70
CHEMBL4645324 IC50 = 0.02 nM 10.70
CHEMBL4645310 IC50 = 0.03 nM 10.52
CHEMBL4638412 IC50 = 0.03 nM 10.52
CHEMBL4644746 IC50 = 0.05 nM 10.30
CHEMBL4635558 IC50 = 0.07 nM 10.15
CHEMBL4633469 IC50 = 0.08 nM 10.10
CHEMBL4643880 IC50 = 0.12 nM 9.92
CHEMBL4642335 IC50 = 0.27 nM 9.57
CHEMBL4640556 IC50 = 0.5 nM 9.30
CHEMBL4640949 IC50 - -
CHEMBL4647900 IC50 - -
CHEMBL4642454 IC50 - -
CHEMBL4649861 IC50 - -
CHEMBL4634939 IC50 - -
CHEMBL4639197 IC50 - -
CHEMBL4634654 IC50 - -