Assay Detail
Binding
CHEMBL4613333
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of sirtuin 6 (unknown origin)
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacylase sirtuin-6 (CHEMBL2163182) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
An overview of Sirtuins as potential therapeutic target: Structure, function and modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.66 | 5.77 |
| EC50 | 1 | 4.42 | 4.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4645806 | — | — | 1 | 5.77 |
| CHEMBL4128547 | — | — | 1 | 5.55 |
| CHEMBL4636092 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4645806 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4128547 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4636092 | — | EC50 | = | 38000.0 | nM | 4.42 |