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Assay Detail

CHEMBL4613334

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of sirtuin 2 (unknown origin)
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

An overview of Sirtuins as potential therapeutic target: Structure, function and modulators.
Wang Y, He J, Liao M, Hu M, Li W, Ouyang H, Wang X, Ye T, Zhang Y, Ouyang L.
Eur J Med Chem (2019) 161 : 48 -77
PubMed 30342425 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 5.35 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4638983 1 7.70
CHEMBL4636862 1 6.96
CHEMBL3236132 1 6.24
CHEMBL3358391 1 6.22
CHEMBL2152613 1 6.00
CHEMBL2164014 1 5.82
CHEMBL4636618 1 5.70
CHEMBL4632578 1 5.65
CHEMBL4644788 1 5.62
CHEMBL4633871 1 5.46
CHEMBL4455153 1 5.42
CHEMBL4638944 1 5.20
CHEMBL1795371 1 5.06
CHEMBL595354 1 5.00
CHEMBL2203548 1 5.00
CHEMBL3222141 1 4.90
CHEMBL1797749 1 4.81
CHEMBL2397737 1 4.70
CHEMBL1483080 1 4.70
CHEMBL226115 1 4.46
CHEMBL4646344 1 4.26
CHEMBL561194 ANILINOBENZAMIDE 1 4.13
CHEMBL2152577 1 4.13

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4638983 IC50 = 20.0 nM 7.70
CHEMBL4636862 IC50 = 110.0 nM 6.96
CHEMBL3236132 IC50 = 570.0 nM 6.24
CHEMBL3358391 IC50 = 600.0 nM 6.22
CHEMBL2152613 IC50 = 1000.0 nM 6.00
CHEMBL2164014 IC50 = 1500.0 nM 5.82
CHEMBL4636618 IC50 = 2000.0 nM 5.70
CHEMBL4632578 IC50 = 2260.0 nM 5.65
CHEMBL4644788 IC50 = 2400.0 nM 5.62
CHEMBL4633871 IC50 = 3500.0 nM 5.46
CHEMBL4455153 IC50 = 3800.0 nM 5.42
CHEMBL4638944 IC50 = 6300.0 nM 5.20
CHEMBL1795371 IC50 = 8700.0 nM 5.06
CHEMBL595354 IC50 = 10000.0 nM 5.00
CHEMBL2203548 IC50 = 10000.0 nM 5.00
CHEMBL3222141 IC50 = 12500.0 nM 4.90
CHEMBL1797749 IC50 = 15500.0 nM 4.81
CHEMBL2397737 IC50 = 20000.0 nM 4.70
CHEMBL1483080 IC50 = 20000.0 nM 4.70
CHEMBL226115 IC50 = 35000.0 nM 4.46
CHEMBL4646344 IC50 = 55000.0 nM 4.26
CHEMBL561194 ANILINOBENZAMIDE IC50 = 74000.0 nM 4.13
CHEMBL2152577 IC50 = 74000.0 nM 4.13