Assay Detail
Binding
CHEMBL4613338
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Inhibition of KDM5B (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Lysine demethylase 5B (KDM5B): A potential anti-cancer drug target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.52 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3785583 | — | — | 1 | 8.33 |
| CHEMBL4454253 | — | — | 1 | 8.00 |
| CHEMBL3775894 | — | — | 1 | 7.85 |
| CHEMBL4078388 | — | — | 1 | 7.72 |
| CHEMBL4637168 | — | — | 1 | 7.70 |
| CHEMBL1336959 | — | — | 1 | 5.52 |
| CHEMBL1686 | ALPHA-KETOGLUTARIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3785583 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4454253 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3775894 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4078388 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4637168 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1336959 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1686 | ALPHA-KETOGLUTARIC ACID | IC50 | = | 800000.0 | nM | - |