Assay Detail
Functional
CHEMBL4614092
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Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by SRB assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of novel phenoxy-diketopiperazine-type plinabulin derivatives as potent antimicrotubule agents based on the co-crystal structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.32 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4634835 | — | — | 1 | 8.42 |
| CHEMBL1096380 | PLINABULIN | 3.0 | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4634835 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL1096380 | PLINABULIN | IC50 | = | 6.0 | nM | 8.22 |