Assay Detail
Binding
CHEMBL4614280
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Inhibition of TRAP1 (unknown origin)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Heat shock protein 75 kDa, mitochondrial (CHEMBL1075132) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.07 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103879 | GANETESPIB | 3.0 | 1 | 7.42 |
| CHEMBL200102 | PU-H71 | 2.0 | 1 | 6.48 |
| CHEMBL4647894 | — | — | 1 | 5.16 |
| CHEMBL4641526 | — | — | 1 | 5.07 |
| CHEMBL4635982 | — | — | 1 | 4.92 |
| CHEMBL4648091 | — | — | 1 | 4.85 |
| CHEMBL4639163 | — | — | 1 | 4.80 |
| CHEMBL4648197 | — | — | 1 | 4.80 |
| CHEMBL4647171 | — | — | 1 | 4.76 |
| CHEMBL4638275 | — | — | 1 | 4.61 |
| CHEMBL4636983 | — | — | 1 | 4.61 |
| CHEMBL4641450 | — | — | 1 | 4.59 |
| CHEMBL4649532 | — | — | 1 | 4.48 |
| CHEMBL4635778 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103879 | GANETESPIB | IC50 | = | 37.7 | nM | 7.42 |
| CHEMBL200102 | PU-H71 | IC50 | = | 330.6 | nM | 6.48 |
| CHEMBL4647894 | — | IC50 | = | 6983.0 | nM | 5.16 |
| CHEMBL4641526 | — | IC50 | = | 8480.0 | nM | 5.07 |
| CHEMBL4635982 | — | IC50 | = | 11883.0 | nM | 4.92 |
| CHEMBL4648091 | — | IC50 | = | 14147.0 | nM | 4.85 |
| CHEMBL4639163 | — | IC50 | = | 15974.0 | nM | 4.80 |
| CHEMBL4648197 | — | IC50 | = | 16014.0 | nM | 4.80 |
| CHEMBL4647171 | — | IC50 | = | 17362.0 | nM | 4.76 |
| CHEMBL4638275 | — | IC50 | = | 24515.0 | nM | 4.61 |
| CHEMBL4636983 | — | IC50 | = | 24487.0 | nM | 4.61 |
| CHEMBL4641450 | — | IC50 | = | 25448.0 | nM | 4.59 |
| CHEMBL4649532 | — | IC50 | = | 33173.0 | nM | 4.48 |
| CHEMBL4635778 | — | IC50 | = | 35102.0 | nM | 4.46 |