Assay Detail
Binding
CHEMBL4614724
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of LAT1-mediated polyamine efflux in human L3.6PL cells assessed as reduction in cell viability after 48 hrs by MTS assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | L3.6pl |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Large neutral amino acids transporter small subunit 1 (CHEMBL4459) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Serendipitous Discovery of Leucine and Methionine Depletion Agents during the Search for Polyamine Transport Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.46 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4642431 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4642431 | — | IC50 | = | 3480.0 | nM | 5.46 |