Assay Detail
Binding
CHEMBL4614752
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Inhibition of human serine protease factor B by TR-FRET based competition binding assay
21
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.35 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4639592 | — | — | 1 | 8.22 |
| CHEMBL4594448 | IPTACOPAN | 4.0 | 1 | 7.92 |
| CHEMBL4641109 | — | — | 1 | 7.75 |
| CHEMBL4632794 | — | — | 1 | 7.75 |
| CHEMBL4644208 | — | — | 1 | 7.75 |
| CHEMBL4646504 | — | — | 1 | 7.62 |
| CHEMBL4644994 | — | — | 3 | 7.48 |
| CHEMBL4646691 | — | — | 2 | 5.60 |
| CHEMBL4645710 | — | — | 1 | 4.92 |
| CHEMBL4645336 | — | — | 1 | 4.57 |
| CHEMBL4635047 | — | — | 2 | 4.44 |
| CHEMBL4633437 | — | — | 2 | 4.17 |
| CHEMBL4646654 | — | — | 1 | - |
| CHEMBL4644769 | — | — | 1 | - |
| CHEMBL4636577 | — | — | 1 | - |
| CHEMBL4647418 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4639592 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4594448 | IPTACOPAN | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4644208 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4632794 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4641109 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4646504 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4644994 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4644994 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4646691 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4646691 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4645710 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4644994 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4645336 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL4635047 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4633437 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL4647418 | — | IC50 | = | 710.0 | nM | - |
| CHEMBL4636577 | — | IC50 | = | 1300.0 | nM | - |
| CHEMBL4644769 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4633437 | — | IC50 | = | 720.0 | nM | - |
| CHEMBL4635047 | — | IC50 | = | 6800.0 | nM | - |
| CHEMBL4646654 | — | IC50 | > | 100000.0 | nM | - |