Assay Detail
Functional
CHEMBL4614818
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Cytotoxicity against human HT-29 cells after 72 hrs by CellTiter 96 Aqueous One Solution reagent based assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Na<sup>+</sup>/K<sup>+</sup>-ATPase-Targeted Cytotoxicity of (+)-Digoxin and Several Semisynthetic Derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.71 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 9.10 |
| CHEMBL254219 | DIGITOXIN | 4.0 | 1 | 7.17 |
| CHEMBL1751 | DIGOXIN | 4.0 | 1 | 6.55 |
| CHEMBL1153 | DIGOXIGENIN | — | 1 | 5.44 |
| CHEMBL4645702 | — | — | 1 | 5.29 |
| CHEMBL4646176 | — | — | 1 | - |
| CHEMBL4642134 | — | — | 1 | - |
| CHEMBL4633690 | — | — | 1 | - |
| CHEMBL4634645 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL254219 | DIGITOXIN | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1751 | DIGOXIN | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1153 | DIGOXIGENIN | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4645702 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4646176 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4642134 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4633690 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4634645 | — | IC50 | > | 10000.0 | nM | - |