Assay Detail
Functional
CHEMBL4614819
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Cytotoxicity against human MDA-MB-231 cells after 72 hrs by CellTiter 96 Aqueous One Solution reagent based assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Na<sup>+</sup>/K<sup>+</sup>-ATPase-Targeted Cytotoxicity of (+)-Digoxin and Several Semisynthetic Derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.40 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.57 |
| CHEMBL1751 | DIGOXIN | 4.0 | 1 | 6.51 |
| CHEMBL254219 | DIGITOXIN | 4.0 | 1 | 6.32 |
| CHEMBL1153 | DIGOXIGENIN | — | 1 | 5.50 |
| CHEMBL4645702 | — | — | 1 | 5.09 |
| CHEMBL4646176 | — | — | 1 | - |
| CHEMBL4642134 | — | — | 1 | - |
| CHEMBL4633690 | — | — | 1 | - |
| CHEMBL4634645 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL1751 | DIGOXIN | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL254219 | DIGITOXIN | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1153 | DIGOXIGENIN | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4645702 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4646176 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4642134 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4633690 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4634645 | — | IC50 | > | 10000.0 | nM | - |