Assay Detail
Functional
CHEMBL4615220
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV J6/JFH/JC1 infected in human Huh7.5 cells incubated for 72 hrs by In-Cell Western assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-((4-Arylpiperazin-1-yl)methyl)benzonitrile Derivatives as Orally Available Inhibitors of Hepatitis C Virus with a Novel Mechanism of Action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 40 | 6.06 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4634954 | — | — | 1 | 7.08 |
| CHEMBL4634052 | — | — | 1 | 6.98 |
| CHEMBL1259059 | SOFOSBUVIR | 4.0 | 1 | 6.98 |
| CHEMBL4642073 | — | — | 1 | 6.85 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 6.84 |
| CHEMBL4642093 | — | — | 1 | 6.82 |
| CHEMBL4634414 | — | — | 1 | 6.78 |
| CHEMBL4634469 | — | — | 1 | 6.69 |
| CHEMBL4642037 | — | — | 1 | 6.69 |
| CHEMBL4645913 | — | — | 1 | 6.66 |
| CHEMBL4638700 | — | — | 1 | 6.54 |
| CHEMBL4634595 | — | — | 1 | 6.50 |
| CHEMBL4635186 | — | — | 1 | 6.50 |
| CHEMBL4635696 | — | — | 1 | 6.49 |
| CHEMBL4642154 | — | — | 1 | 6.40 |
| CHEMBL4636045 | — | — | 1 | 6.37 |
| CHEMBL4644672 | — | — | 1 | 6.34 |
| CHEMBL4639593 | — | — | 1 | 6.30 |
| CHEMBL4647605 | — | — | 1 | 6.18 |
| CHEMBL4638137 | — | — | 1 | 6.13 |
| CHEMBL4636952 | — | — | 1 | 6.11 |
| CHEMBL4642208 | — | — | 1 | 6.09 |
| CHEMBL4640104 | — | — | 1 | 6.04 |
| CHEMBL4646655 | — | — | 1 | 6.03 |
| CHEMBL4648613 | — | — | 1 | 6.02 |
| CHEMBL4634675 | — | — | 1 | 5.98 |
| CHEMBL4633863 | — | — | 1 | 5.94 |
| CHEMBL4634801 | — | — | 1 | 5.88 |
| CHEMBL4635515 | — | — | 1 | 5.84 |
| CHEMBL4648516 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4634954 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4634052 | — | EC50 | = | 104.0 | nM | 6.98 |
| CHEMBL1259059 | SOFOSBUVIR | EC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4642073 | — | EC50 | = | 142.0 | nM | 6.85 |
| CHEMBL231813 | TELAPREVIR | EC50 | = | 146.0 | nM | 6.84 |
| CHEMBL4642093 | — | EC50 | = | 153.0 | nM | 6.82 |
| CHEMBL4634414 | — | EC50 | = | 166.0 | nM | 6.78 |
| CHEMBL4634469 | — | EC50 | = | 205.0 | nM | 6.69 |
| CHEMBL4642037 | — | EC50 | = | 203.0 | nM | 6.69 |
| CHEMBL4645913 | — | EC50 | = | 217.0 | nM | 6.66 |
| CHEMBL4638700 | — | EC50 | = | 289.0 | nM | 6.54 |
| CHEMBL4634595 | — | EC50 | = | 314.0 | nM | 6.50 |
| CHEMBL4635186 | — | EC50 | = | 318.0 | nM | 6.50 |
| CHEMBL4635696 | — | EC50 | = | 321.0 | nM | 6.49 |
| CHEMBL4642154 | — | EC50 | = | 399.0 | nM | 6.40 |
| CHEMBL4636045 | — | EC50 | = | 423.0 | nM | 6.37 |
| CHEMBL4644672 | — | EC50 | = | 454.0 | nM | 6.34 |
| CHEMBL4639593 | — | EC50 | = | 506.0 | nM | 6.30 |
| CHEMBL4647605 | — | EC50 | = | 657.0 | nM | 6.18 |
| CHEMBL4638137 | — | EC50 | = | 749.0 | nM | 6.13 |
| CHEMBL4636952 | — | EC50 | = | 783.0 | nM | 6.11 |
| CHEMBL4642208 | — | EC50 | = | 814.0 | nM | 6.09 |
| CHEMBL4640104 | — | EC50 | = | 902.0 | nM | 6.04 |
| CHEMBL4646655 | — | EC50 | = | 936.0 | nM | 6.03 |
| CHEMBL4648613 | — | EC50 | = | 952.0 | nM | 6.02 |
| CHEMBL4634675 | — | EC50 | = | 1051.0 | nM | 5.98 |
| CHEMBL4633863 | — | EC50 | = | 1155.0 | nM | 5.94 |
| CHEMBL4634801 | — | EC50 | = | 1326.0 | nM | 5.88 |
| CHEMBL4635515 | — | EC50 | = | 1435.0 | nM | 5.84 |
| CHEMBL4648516 | — | EC50 | = | 1869.0 | nM | 5.73 |
| CHEMBL4637562 | — | EC50 | = | 2511.0 | nM | 5.60 |
| CHEMBL4643593 | — | EC50 | = | 2737.0 | nM | 5.56 |
| CHEMBL4648358 | — | EC50 | = | 4694.0 | nM | 5.33 |
| CHEMBL4648183 | — | EC50 | = | 6427.0 | nM | 5.19 |
| CHEMBL4646217 | — | EC50 | = | 7293.0 | nM | 5.14 |
| CHEMBL4644463 | — | EC50 | = | 13705.0 | nM | 4.86 |
| CHEMBL4645571 | — | EC50 | = | 35011.0 | nM | 4.46 |
| CHEMBL4643103 | — | EC50 | = | 57519.0 | nM | 4.24 |
| CHEMBL4640273 | — | EC50 | = | 79380.0 | nM | 4.10 |
| CHEMBL4644532 | — | EC50 | = | 118954.0 | nM | - |