Assay Detail
Binding
CHEMBL4615387
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Binding affinity to BRD4 (1) (unknown origin) N-terminal bromodomain by TR-FRET assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.72 | 4.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4639281 | — | — | 1 | 4.90 |
| CHEMBL4633192 | — | — | 1 | 4.90 |
| CHEMBL4643455 | — | — | 1 | 4.90 |
| CHEMBL4644816 | — | — | 1 | 4.80 |
| CHEMBL4095646 | — | — | 1 | 4.70 |
| CHEMBL4642945 | — | — | 1 | 4.70 |
| CHEMBL4645392 | — | — | 1 | 4.70 |
| CHEMBL4647246 | — | — | 1 | 4.60 |
| CHEMBL4645268 | — | — | 1 | 4.60 |
| CHEMBL4645137 | — | — | 1 | 4.40 |
| CHEMBL4093233 | — | — | 1 | - |
| CHEMBL4646728 | — | — | 1 | - |
| CHEMBL4648548 | — | — | 1 | - |
| CHEMBL4643740 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4639281 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL4633192 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL4643455 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL4644816 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL4095646 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL4642945 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL4645392 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL4647246 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL4645268 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL4645137 | — | IC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL4093233 | — | IC50 | = | 125892.54 | nM | - |
| CHEMBL4646728 | — | IC50 | > | 50118.72 | nM | - |
| CHEMBL4648548 | — | IC50 | > | 50118.72 | nM | - |
| CHEMBL4643740 | — | IC50 | > | 50118.72 | nM | - |