Assay Detail
Functional
CHEMBL4615431
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Antiviral activity against HIV2 ROD infected in thymidine kinase-deficient human CEM cells assessed as inhibition of virus-induced giant cell formation measured after 4 to 5 days by microscopic analysis
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Anti-HIV-Active Nucleoside Triphosphate Prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 6.17 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4648734 | — | — | 1 | 7.14 |
| CHEMBL4635962 | — | — | 1 | 6.96 |
| CHEMBL4646773 | — | — | 1 | 6.92 |
| CHEMBL4644604 | — | — | 1 | 6.82 |
| CHEMBL4642210 | — | — | 1 | 6.68 |
| CHEMBL4638265 | — | — | 1 | 6.64 |
| CHEMBL4638487 | — | — | 1 | 6.62 |
| CHEMBL4634977 | — | — | 1 | 6.25 |
| CHEMBL4633617 | — | — | 1 | 6.19 |
| CHEMBL4633979 | — | — | 1 | 5.95 |
| CHEMBL4648985 | — | — | 1 | 5.84 |
| CHEMBL4636479 | — | — | 1 | 5.76 |
| CHEMBL4633512 | — | — | 1 | 5.75 |
| CHEMBL4638949 | — | — | 1 | 5.70 |
| CHEMBL4639741 | — | — | 1 | 5.61 |
| CHEMBL4637807 | — | — | 1 | 5.49 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4648734 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4635962 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4646773 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4644604 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4642210 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4638265 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4638487 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4634977 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4633617 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4633979 | — | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL4648985 | — | EC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL4636479 | — | EC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL4633512 | — | EC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL4638949 | — | EC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL4639741 | — | EC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL4637807 | — | EC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL991 | STAVUDINE | EC50 | = | 31050.0 | nM | 4.51 |