Assay Detail
Binding
CHEMBL4615734
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC6 in mouse N2A cells assessed as increase in alpha tubulin acetylation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | N2a |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.49 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 6.84 |
| CHEMBL4636622 | — | — | 1 | 6.60 |
| CHEMBL3970950 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2018302 | TUBASTATIN A | EC50 | = | 145.0 | nM | 6.84 |
| CHEMBL4636622 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3970950 | — | EC50 | = | 932.0 | nM | 6.03 |