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Assay Detail

CHEMBL4615885

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against blood stage form of Trypanosoma brucei brucei 449 incubated for 24 hrs by ATPlite assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei brucei
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei brucei (CHEMBL612851)
Type ORGANISM
Organism Trypanosoma brucei brucei

Publication

Drug Synergism: Studies of Combination of RK-52 and Curcumin against Rhodesain of <i>Trypanosoma brucei rhodesiense</i>.
Ettari R, Previti S, Di Chio C, Maiorana S, Allegra A, Schirmeister T, Zappalà M.
ACS Med Chem Lett (2020) 11 : 806 -810
PubMed 32435388 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.57 5.63

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4078345 1 5.63
CHEMBL140 CURCUMIN 3.0 1 5.51

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4078345 IC50 = 2330.0 nM 5.63
CHEMBL140 CURCUMIN IC50 = 3120.0 nM 5.51