Assay Detail
Functional
CHEMBL4615965
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Antiproliferative activity against human A375 cells assessed as reduction in cell viability incubated for 72 hrs by trypan blue or crystal violet staining based assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.57 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4291780 | — | — | 1 | 6.40 |
| CHEMBL4646579 | — | — | 1 | 6.22 |
| CHEMBL4641692 | — | — | 1 | 5.92 |
| CHEMBL4645975 | — | — | 1 | 5.70 |
| CHEMBL4643015 | — | — | 1 | 5.66 |
| CHEMBL323197 | MANGOSTIN | — | 1 | 5.57 |
| CHEMBL4637567 | — | — | 1 | 5.57 |
| CHEMBL4633896 | — | — | 1 | 5.39 |
| CHEMBL4633034 | — | — | 1 | 5.30 |
| CHEMBL4643508 | — | — | 1 | 5.29 |
| CHEMBL4635710 | — | — | 1 | 5.28 |
| CHEMBL4638847 | — | — | 1 | 5.21 |
| CHEMBL4648023 | — | — | 1 | 4.92 |
| CHEMBL4637439 | — | — | 1 | - |
| CHEMBL4649673 | — | — | 1 | - |
| CHEMBL4644262 | — | — | 1 | - |
| CHEMBL4642162 | — | — | 1 | - |
| CHEMBL4649038 | — | — | 1 | - |
| CHEMBL4634568 | — | — | 1 | - |
| CHEMBL2171891 | — | — | 1 | - |
| CHEMBL1464513 | — | — | 1 | - |
| CHEMBL4647537 | — | — | 1 | - |
| CHEMBL4648497 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4291780 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4646579 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4641692 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4645975 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4643015 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL323197 | MANGOSTIN | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4637567 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4633896 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4633034 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4643508 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4635710 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4638847 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4648023 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4637439 | — | IC50 | - | — | - | |
| CHEMBL4649673 | — | IC50 | - | — | - | |
| CHEMBL4644262 | — | IC50 | - | — | - | |
| CHEMBL4642162 | — | IC50 | - | — | - | |
| CHEMBL4649038 | — | IC50 | - | — | - | |
| CHEMBL4634568 | — | IC50 | - | — | - | |
| CHEMBL2171891 | — | IC50 | - | — | - | |
| CHEMBL1464513 | — | IC50 | - | — | - | |
| CHEMBL4647537 | — | IC50 | - | — | - | |
| CHEMBL4648497 | — | IC50 | - | — | - |