Assay Detail
Binding
CHEMBL4616295
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Binding affinity to human TERT G4-quadruplex DNA assessed as dissociation equilibrium binding constant by intrinsic fluorescence titration based fluorescence spectrophotometry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.20 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2335138 | — | — | 1 | 8.40 |
| CHEMBL4640542 | QN-302 | 1.0 | 1 | 8.40 |
| CHEMBL4103012 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2335138 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL4640542 | QN-302 | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL4103012 | — | Kd | = | 16.0 | nM | 7.80 |