Assay Detail
Binding
CHEMBL4616525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ATX by LPC choline release assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Indole-Based Allosteric Highly Potent ATX Inhibitors with Great In Vivo Efficacy in a Mouse Lung Fibrosis Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.05 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4086925 | — | — | 1 | 7.22 |
| CHEMBL3828074 | ZIRITAXESTAT | 3.0 | 1 | 6.88 |
| CHEMBL4642052 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4086925 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3828074 | ZIRITAXESTAT | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL4642052 | — | IC50 | < | 500.0 | nM | - |