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Assay Detail

CHEMBL4616962

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of beta-glucuronidase (unknown origin)
ChEMBL ↗
109
Total Activities
109
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Beta-glucuronidase (CHEMBL2728) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Therapeutic significance of β-glucuronidase activity and its inhibitors: A review.
Awolade P, Cele N, Kerru N, Gummidi L, Oluwakemi E, Singh P.
Eur J Med Chem (2020) 187 : 111921 -111921
PubMed 31835168 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 109 5.49 8.93

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3980115 — — 1 8.93
CHEMBL4635113 — — 1 7.70
CHEMBL4642420 — — 1 6.93
CHEMBL4641808 — — 1 6.85
CHEMBL3903683 — — 1 6.55
CHEMBL4640688 — — 1 6.46
CHEMBL4641364 — — 1 6.43
CHEMBL4642057 — — 1 6.33
CHEMBL4644690 — — 1 6.30
CHEMBL4634026 — — 1 6.27
CHEMBL4475955 — — 1 6.26
CHEMBL4638527 — — 1 6.22
CHEMBL137922 — — 1 6.22
CHEMBL3289121 — — 1 6.16
CHEMBL4544953 — — 1 6.12
CHEMBL4649515 — — 1 6.12
CHEMBL4632679 — — 1 6.12
CHEMBL4638475 — — 1 6.10
CHEMBL4589941 — — 1 6.07
CHEMBL4643721 — — 1 6.05
CHEMBL4636614 — — 1 5.96
CHEMBL4647461 — — 1 5.96
CHEMBL4632864 — — 1 5.92
CHEMBL4649752 — — 1 5.92
CHEMBL4649082 — — 1 5.89
CHEMBL4642391 — — 1 5.80
CHEMBL150755 — — 1 5.80
CHEMBL4635474 — — 1 5.74
CHEMBL4633676 — — 1 5.73
CHEMBL4637667 — — 1 5.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3980115 — IC50 = 1.17 nM 8.93
CHEMBL4635113 — IC50 = 20.0 nM 7.70
CHEMBL4642420 — IC50 = 118.0 nM 6.93
CHEMBL4641808 — IC50 = 142.0 nM 6.85
CHEMBL3903683 — IC50 = 280.0 nM 6.55
CHEMBL4640688 — IC50 = 347.0 nM 6.46
CHEMBL4641364 — IC50 = 370.0 nM 6.43
CHEMBL4642057 — IC50 = 468.0 nM 6.33
CHEMBL4644690 — IC50 = 500.0 nM 6.30
CHEMBL4634026 — IC50 = 540.0 nM 6.27
CHEMBL4475955 — IC50 = 550.0 nM 6.26
CHEMBL137922 — IC50 = 600.0 nM 6.22
CHEMBL4638527 — IC50 = 600.0 nM 6.22
CHEMBL3289121 — IC50 = 700.0 nM 6.16
CHEMBL4649515 — IC50 = 759.0 nM 6.12
CHEMBL4544953 — IC50 = 750.0 nM 6.12
CHEMBL4632679 — IC50 = 759.0 nM 6.12
CHEMBL4638475 — IC50 = 800.0 nM 6.10
CHEMBL4589941 — IC50 = 850.0 nM 6.07
CHEMBL4643721 — IC50 = 900.0 nM 6.05
CHEMBL4636614 — IC50 = 1100.0 nM 5.96
CHEMBL4647461 — IC50 = 1100.0 nM 5.96
CHEMBL4649752 — IC50 = 1200.0 nM 5.92
CHEMBL4632864 — IC50 = 1200.0 nM 5.92
CHEMBL4649082 — IC50 = 1300.0 nM 5.89
CHEMBL150755 — IC50 = 1600.0 nM 5.80
CHEMBL4642391 — IC50 = 1600.0 nM 5.80
CHEMBL4635474 — IC50 = 1820.0 nM 5.74
CHEMBL4633676 — IC50 = 1860.0 nM 5.73
CHEMBL4637667 — IC50 = 1900.0 nM 5.72
CHEMBL4646284 — IC50 = 2100.0 nM 5.68
CHEMBL3785671 — IC50 = 2160.0 nM 5.67
CHEMBL4637950 — IC50 = 2200.0 nM 5.66
CHEMBL4632787 — IC50 = 2200.0 nM 5.66
CHEMBL1941007 — IC50 = 2300.0 nM 5.64
CHEMBL1255773 — IC50 = 2300.0 nM 5.64
CHEMBL4634327 — IC50 = 2270.0 nM 5.64
CHEMBL4637062 — IC50 = 2300.0 nM 5.64
CHEMBL4642859 — IC50 = 2500.0 nM 5.60
CHEMBL4649019 — IC50 = 2600.0 nM 5.58
CHEMBL4648433 — IC50 = 2800.0 nM 5.55
CHEMBL4567497 — IC50 = 2810.0 nM 5.55
CHEMBL4647107 — IC50 = 3100.0 nM 5.51
CHEMBL4632701 — IC50 = 3100.0 nM 5.51
CHEMBL4640639 — IC50 = 3100.0 nM 5.51
CHEMBL4633460 — IC50 = 3200.0 nM 5.50
CHEMBL4639449 — IC50 = 3300.0 nM 5.48
CHEMBL4640964 — IC50 = 3340.0 nM 5.48
CHEMBL4639737 — IC50 = 3600.0 nM 5.44
CHEMBL403038 — IC50 = 3600.0 nM 5.44