Assay Detail
Binding
CHEMBL4616980
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli beta-glucuronidase using p-nitrophenyl-beta-D-glucuronide as substrate
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Beta-glucuronidase (CHEMBL3217380) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli (strain K12) |
Publication
Therapeutic significance of β-glucuronidase activity and its inhibitors: A review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.65 | 7.75 |
| IC50 | 1 | 4.20 | 4.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3903683 | — | — | 1 | 7.75 |
| CHEMBL4641364 | — | — | 1 | 7.55 |
| CHEMBL4641100 | — | — | 1 | 4.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3903683 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4641364 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4641100 | — | IC50 | = | 63000.0 | nM | 4.20 |