Assay Detail
Binding
CHEMBL4616982
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Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-d-glucuronide as substrate after 30 mins by spectrophotometric analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Therapeutic significance of β-glucuronidase activity and its inhibitors: A review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.90 | 5.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3785671 | — | — | 1 | 5.67 |
| CHEMBL4639507 | — | — | 1 | 5.62 |
| CHEMBL3786740 | — | — | 1 | 5.38 |
| CHEMBL4635015 | — | — | 1 | 5.20 |
| CHEMBL4649684 | — | — | 1 | 4.95 |
| CHEMBL4634955 | — | — | 1 | 4.91 |
| CHEMBL4637157 | — | — | 1 | 4.84 |
| CHEMBL4637046 | — | — | 1 | 4.74 |
| CHEMBL4632467 | — | — | 1 | 4.72 |
| CHEMBL4635098 | — | — | 1 | 4.60 |
| CHEMBL4639994 | — | — | 1 | 4.53 |
| CHEMBL4637951 | — | — | 1 | 4.42 |
| CHEMBL4633556 | — | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3785671 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL4639507 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3786740 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL4635015 | — | IC50 | = | 6340.0 | nM | 5.20 |
| CHEMBL4649684 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL4634955 | — | IC50 | = | 12260.0 | nM | 4.91 |
| CHEMBL4637157 | — | IC50 | = | 14550.0 | nM | 4.84 |
| CHEMBL4637046 | — | IC50 | = | 18380.0 | nM | 4.74 |
| CHEMBL4632467 | — | IC50 | = | 19060.0 | nM | 4.72 |
| CHEMBL4635098 | — | IC50 | = | 25060.0 | nM | 4.60 |
| CHEMBL4639994 | — | IC50 | = | 29250.0 | nM | 4.53 |
| CHEMBL4637951 | — | IC50 | = | 38380.0 | nM | 4.42 |
| CHEMBL4633556 | — | IC50 | = | 76400.0 | nM | 4.12 |