Assay Detail
Binding
CHEMBL4617593
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IL-6 induced STAT3 phosphorylation at Tyr705 residue in human MCF7 cells preincubated for 1 hr followed by IL-6 stimulation and measured after 1 hr by Western blot analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 3 (CHEMBL4026) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
STAT3 inhibitory activity of naphthoquinones isolated from Tabebuia avellanedae.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.70 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL392591 | — | — | 1 | 5.70 |
| CHEMBL611361 | — | — | 1 | 5.70 |
| CHEMBL64130 | NAPABUCASIN | 3.0 | 1 | - |
| CHEMBL4635140 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL392591 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL611361 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL64130 | NAPABUCASIN | IC50 | < | 1000.0 | nM | - |
| CHEMBL4635140 | — | IC50 | < | 1000.0 | nM | - |