Assay Detail
Binding
CHEMBL4617627
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Inhibition of SIRT2 deacetylation activity (unknown origin) using H3K9Ac ( 4 to 15 residues) as substrate by HPLC analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Unexpected small molecules as novel SIRT2 suicide inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.65 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770903 | — | — | 1 | 6.22 |
| CHEMBL4643733 | — | — | 1 | 4.84 |
| CHEMBL4638076 | — | — | 1 | 4.37 |
| CHEMBL4634872 | — | — | 1 | 4.25 |
| CHEMBL4634985 | — | — | 1 | 4.13 |
| CHEMBL4640752 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770903 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4643733 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL4638076 | — | IC50 | = | 42700.0 | nM | 4.37 |
| CHEMBL4634872 | — | IC50 | = | 56600.0 | nM | 4.25 |
| CHEMBL4634985 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL4640752 | — | IC50 | = | 77100.0 | nM | 4.11 |