Assay Detail
Binding
CHEMBL4617628
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SIRT3 deacetylation activity (unknown origin) using H3K9Ac (4 to 15 residues) as substrate by HPLC analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (CHEMBL4461) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Unexpected small molecules as novel SIRT2 suicide inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.12 | 4.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4640752 | — | — | 1 | 4.17 |
| CHEMBL4634985 | — | — | 1 | 4.07 |
| CHEMBL3770903 | — | — | 1 | - |
| CHEMBL4634872 | — | — | 1 | - |
| CHEMBL4638076 | — | — | 1 | - |
| CHEMBL4643733 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4640752 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL4634985 | — | IC50 | = | 84900.0 | nM | 4.07 |
| CHEMBL3770903 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4634872 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4638076 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4643733 | — | IC50 | > | 200000.0 | nM | - |